This paper explores pandemic planning efforts across federal and state jurisdictions and how the absence of collaboration could have major consequences upon the population of the United States. How adequate are state and federal pandemic plans, and what must be done nationally to address common shortfalls? The methodology used a hybrid approach by combining a secondary analysis of available data with a modified case study approach. Analyzing the individual state plans and HHS’ Pandemic Influenza Plan revealed common deficiencies, and disclosed distinct functional areas where stringent collaboration across multiple jurisdictions and functional areas would mitigate the deficiencies and provide a blueprint for potential development into an all-hazards national catastrophe plan. This resultant comprehensive plan would provide a solid template for all stakeholders to use in further development of their individual plans, and additionally provide a mechanism to propagate proactive planning efforts among international disaster preparedness partners.