The development and implementation of advanced aerospace vehicles is an endeavor that can potentially affect long-term aviation operations and future system capabilities for several decades. Selecting the best vehicle configuration(s) requires a thorough understanding of the capabilities and life-cycle considerations required by the end user, the vehicle’s full spectrum operations, as well as technologies impacting both operational needs and system performance. The fundamental goal of the proposed effort involves using the Aerospace Systems Design Laboratory (ASDL) established expertise in the fields of decision support and advanced vehicle Modeling and Simulation (M&S) to develop an innovative trade-off environment for advanced vehicle concepts exploration.