January 28, 2015
“Discovery consists of seeing what everybody has seen and thinking what nobody has thought,”
Dr. Albert Szent-Gyorgyi
Discoverer of Ascorbic acid
This famous quote by Albert Szent-Gyorgyi, the discoverer of ascorbic acid [also known as (5R)-5-[(1S)-1, 2-Dihydroxyethyl]-3, 4-dihydroxy-2(5H)-furanone)] couldn’t have been a more perfect description of the exceptional observational powers of William J. McCormick M.D. (1880 – 1968 from Toronto, Canada). Dr. McCormick made one of the most controversial and at the same time brilliant observations ever, concerning the dreaded disease known as cancer. He astutely observed that the symptoms of ascorbic acid (vitamin C) deficiency diseases such as scurvy closely resemble some forms of leukemia and some forms of cancer. “The most striking clinical symptoms of this disease are the hemorrhages and their sequelae. . . . Every touch produces hemorrhage, making a condition completely identical with that of scurvy.1” Mainstream medicine considers scurvy to be virtually non-existent in the industrialized countries. While at the same time, cancer is very prevalent in these same industrialized countries. Dr. McCormick adroitly challenges mainstream medical science by posing a question that was conceived from his many years of observing classic scurvy and cancer; “If the signs of cancer and scurvy are similar, could they be the same disease under a different name?1” Unfortunately medical science has never provided an answer to this question.
In 1937 the Nobel Prize in physiology and medicine was awarded to Dr. Szent-Gyorgyi for discovering C6H8O6 and the components and reactions of the citric acid cycle. In 1940 research studies revealed that cancer patients were frequently deficient in ascorbic acid. Intravenous injections of ascorbic acid were given therapeutically to correct the deficiency. (Twenty-nine years later In 1969 optimal doses of intravenous injections of ascorbic acid was proven to be toxic to malignant cancer cells). It is around this time that William J. McCormick M.D noticed a correlation between cancer and a shortage of ascorbic acid. He concluded from his observations that cancer was a disease of faulty collagen (an essential part of the framework of the design of our various body tissues2) production caused by a lack of ascorbic acid. McCormick was one of the first to realize that there was a definite relationship between poor collagen synthesis and a low ascorbic acid intake.
The gold standard of the scientific method is the repeatability of observations and experiments. If a theory is true it should be true every time it is tested. It took a while but in 1971 the scientific method, which relies on the premise of ceteris paribus “all things being equal or held constant3”, began to validate the observations of William J. McCormick.
In 1971 Roger J. Williams PhD (discover of pantothenic acid/B5) proved that “ascorbic acid is essential for the building of collagen, the most abundant protein built in our bodies and the major component of connective tissue. This connective tissue has structural and supportive functions which are indispensable to heart tissues, to blood vessels, --in fact, to all tissues. Collagen is not only the most abundant protein in our bodies, it also occurs in larger amounts than all other proteins put together. It cannot be built without ascorbic acid. No heart or blood vessel or other organ could possibly perform its functions without collagen. No heart or blood vessel can be maintained in healthy condition without ascorbic acid.4”
In his book “How To Live Longer and Feel Better” (1986) two-time (unshared) Nobel Laureate Linus Pauling PhD, who ushered in the era of Orthomolecular medicine, is quoted saying in stunning detail that “the synthesis of collagen, for which vitamin C (ascorbic acid) is essential, proceeds in the body as one of its major manufacturing enterprises. A person who is dying of scurvy stops making this substance, and his body falls apart -- his joints fail, because he can no longer keep the cartilage and tendons strong, his blood vessels break open, his gums ulcerate and his teeth fall out, his immune system deteriorates, and he dies.
Collagen is a protein, one of the thousands of different kinds of proteins in the human body. Most proteins occur in only small amounts: the various enzymes, for example, are so powerful in their ability to cause specific chemical reactions to take place rapidly that only a gram or two or even a few milligrams may be needed in the body. There are a few exceptions. There is a great amount of hemoglobin in red blood cells. There is even more collagen in the skin, bones, teeth, blood vessels, eye, heart, and, in fact, essentially all parts of the body. Collagen as strong white fibers, stronger than steel wire of the same weight, and as yellow elastic networks (called elastin), usually together with macropolysaccharides, constitutes the connective tissue that holds our bodies together.
We have come upon the two big reasons why we require, so much larger amounts of vitamin C (ascorbic acid) for good health than are present in the plants we use as food. First, there is the bodies’ continuing need for the synthesis of large amounts of collagen for growth and for replacement of the collagen degraded by daily wear and tear. Second, vitamin C, in the critical reactions that assemble collagen in the tissues, does not serve merely as a catalyst but is destroyed.5" Since, C6H8O6 is so vital for the growth and replacement of collagen why it is that evolution has deactivated the L-gulono-γ-lactone oxidase molecule in the last step in the biosynthesis of ascorbic acid? From an evolutionary standpoint this does not make sense.
The result of Dr. McCormick’s extraordinary observational skills has led to the discovery of a scientific law concerning the global health of the Homo sapien species. This scientific law is referred to as McCormick’s Law. The language of McCormick’s Law was written by Andrew W. Saul PhD in 2003 as a tribute to his outstanding work. This law states that “disease trends in history might be understood as waves of lack of vitamin C intake6”. It is very unfortunate that McCormick’s Law is not even considered as an afterthought (change of mind) by mainstream medical science when there are no obvious causes for epidemics or pandemics.
McCormick’s Law explains why there are disease outbreaks and at the same time offers an inexpensive treatment for these outbreaks - ascorbic acid. Other micronutrients can be used, but the initial usage of C6H8O6 is very important because it is an excellent free radical scavenger. In the early part of the 21st century there are worldwide outbreaks of disease, such as the “Ebola outbreak” in several West African countries, a deadly airborne plague in Denver, the Chikungunya virus which originated in the tropical Americas (and is now present in 35 states in the U.S.A). Drug-resistant infections exploded by 500% across United States hospitals. MERS (Middle East Respiratory Syndrome) has mutated into an airborne pathogen. The Chinese government has quarantined an entire city after an outbreak of the bubonic plague. The bubonic plague is an infectious disease caused by the bacteria Yersinia pestis that is carried by rodents. Insect plague (mayfly hatch in the Mississippi River) reached Biblical proportions in Wisconsin.7” Wars in the Middle East and Ukraine are having a deleterious effect on the indigenous supply of ascorbic acid by ravaging the environment, and thus the beat goes on!
Conventional science has no measurable standard by which to determine the average or normal amount of planetary ascorbic acid (such as how many quintillion metric tons) required to sustain a healthy environment. The Earth is going through a period of rapid climate change. It would be presumptuous to think that rapid changes in the environment would not have an adverse effect on the environmental availability of ascorbic acid. Since, it is not known what amount of C6H8O6 is needed to sustain life on a planetary scale, without this knowledge all human activity on this planet is tantamount to playing Russian roulette. This lethal game of chance will invariably one day initiate an extinction level event (a widespread and rapid decrease in the amount of life on Earth).
To summarize, McCormick’s Law was named after William J. McCormick a physician from Toronto, Canada. The law states that when humans consume subnormal levels of environmental ascorbic acid, this will have an adverse effect on the production of collagen. The production of defective collagen results in scurvy. Scurvy is basically the disintegration of collagen. Collagen is the mortar that binds all cells together. The degradation of collagen weakens the cellular walls to such an extent that opportunistic microorganisms invade these cells to further exploit an already weakened immune system.
]Historically there are two major events that were affected by a lethal decline in the environmental accessibility of ascorbic acid. The first was the Biblical floods and the second was the extinction of the Dinosaurs. There are two planetary extremes which contain very little or no environmental ascorbic acid. The first is a planetary desert, and the other is a planetary water world. The science of Alternative knowledge (“information rooted in mainstream science, but in areas normally kept from public discussion because they cast doubt on the currently accepted paradigms and dogmas of the mainstream,”8) theorizes that there exists enough compelling evidence to demonstrate that the planet Earth has experienced global flooding in the past. What is perplexing is that widespread among the many different cultures is a similarity to the Mesopotamian/Sumerian flood stories, the Puranas, Deucalion in Greek mythology, the Genesis flood narrative, and in the body of knowledge of the K'iche' and Maya peoples in Mesoamerica, the Lac Courte Oreilles Ojibwa tribe of Native Americans in North America, the Muisca people, and Cañari Confederation, in South America.
According to ancient myths, the purpose of global flooding was the targeted destruction of human civilization. It has been hypothesized that global flooding was not directed at the destruction of mankind, but instead was targeted at the unstable and transient nature of ascorbic acid, which in turn would kill off those species which are unable to synthesize their own ascorbic acid apes (primates), guinea pigs, fruit eating bat (Pteropus medius) from India, and passeriforme birds (perching birds). The destruction of environmental ascorbic acid would ensure the elimination of those humans who did not possess the L-gulono-γ-lactone oxidase molecule. This enzyme would have provided humans with the ability to internally synthesize ascorbic acid. Without the GLO enzyme in about 3 to 5 months humans would exhibit symptoms of scurvy and eventually would succumb to a whole range of subclinical scurvy type diseases.
1. Mild cold
2. Severe Cold
4. ECHO (Enteric Cytopathogenic Human Orphan Group), Coxsackievirus (group of viruses that lead to gastrointestinal infection and skin rashes)
6. Viral Pneumonia
7. Hay Fever, Environmental Asthma and Food Allergy.
8. Burns, injury, surgery anxiety, exercise, and other mild stresses.
10. Ankylosing Spondylitis (chronic inflammatory disease of the axial skeleton)
11. Reiters Syndrome (Reactive arthritis)
12. Acute Anterior Uveitis (inflammation of the middle layer of the eye)
13. Rheumatoid Arthritis
14. Bacterial Infections
15. Hepatitis Infection
16. Candidiasis (fungal infection)
17. Scarlet Fever
18. Herpes: Cold Sores, Genital Lesions, and Shingles
19. Crib Deaths (Sudden Infant Death Syndrome)
One day, Paleontologists will finally realize the importance of Indu. B. Chatterjee’s PhD theory that environmental hyperoxia was a major factor in the extinction of the dinosaurs. The persistence of high concentrations of O2 during the Carboniferous-Permian period may have been a major factor in the accelerated diversification and mass extinction of the tetrapods (the amphibians, reptiles, birds, and mammals; these four groups are united by the fact that most animals in each group have four limbs). The mass extinction was credited to be at the end of the Permian period. Dr. Chatterjee theorizes there was probably no sudden catastrophic event such as a comet or asteroid crashing into the earth. It is presumed that this extinction event was spread over millions of years. Dr. Chatterjee postulates that “global hyperoxia leading to oxygen toxicity might be the causative factor for the extinction of most of the early amphibians and reptiles.10” The environmental supply of ascorbic acid was not enough to counteract the effects of hyperoxia. The only defense animals had against oxygen toxicity was to have the ability to produce ascorbic acid. The production of ascorbic acid would have allowed these animals to successfully survive in a hyperoxia environment.
Imagine in a far off place, a high level meeting is occurring. The discussion is about the fact that the planet Earth, along with its stewards the human beings, is dying. The bio system of planet Earth is dying because the stewards could not solve their problems of avarice and global poverty. These two intractable problems have adversely affected the amount of environmentally available ascorbic acid to such an extent that global populations could not take in enough ascorbic acid to maintain a level of good health. Global pandemics have wreaked havoc among the indigent peoples of the world. Just like in any high level meeting there is a small but vocal contingent that says, “let them die.” The other attendees who are, hopefully, moderates realize that mankind is on the precipice of extinction. They are cautiously optimistic that at this point in time mankind may possess the will to change!
Mankind’s inability to internally synthesize ascorbic acid has left humans totally dependent on the easy accessibility of environmental ascorbic acid that Earth provides. Conventional medical science does not consider being hypoascorbemic a medical problem. This dependency on external sources of ascorbic acid has permanently tethered mankind to this planet. Without any practical solutions to solving this problem of being chronically hypoascorbemic, mankind’s instinctive passion, for deep space exploration will be relegated only to robots and the imagination of science fiction writers.
1. Hickey, PhD, Steve & Saul, PhD. W. Andrew. Vitamin C: The Real Story, Chapter 2, page 33. Basic Health Publications, Inc. 2008
2. Collagen definition-MedicineNet-Health and Medical Information Produced by Doctors. http://www.medicinenet.com/script/main/ ... lekey=2786
3. Ceteris paribus – Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Ceteris_parabus
4. Roger J. Williams, Nutrition Against Disease, 1971. Pg. 85-86 (paperback), Vitamin C and Collagen. Http//www.vitamincfoundation.org/collagen.html
5. Linus Pauling, How to Live Longer and Feel Better, 1986. Pages 89-91, Vitamin C and Collagen. Http//www.vitamincfoundation.org/collagen.html
6. Hoffer, MD, PhD, Abram & Saul, PhD. W. Andrew. Orthomolecular Medicine For Everyone, Chapter 4, page 92. Basic Health Publications, Inc. 2008
7. Is this the beginning of Biblical-class plague?
http://www.naturalnews.com/046146_Bibli ... sease.html
8. “Alternative Knowledge”,
https://eses.facebook.com/TheConspiracy ... 4786918495
9. Flood Myth- Wikipedia, the free encyclopedia. http://en.wikipedia.org/wiki/Flood_myth
10. Chatterjee, Indu, B., Nandi, Anuradha, Mukhopadhyay, Chinmay,K., Ghosh, Mrinal, K.,Chattopadhyay, Dhruba, J. “Evolutionary Significance of Vitamin C Biosynthesis in Terrestrial Vertebrates.” Free Radical Biology &Medicine, Volume 22, No. 6 pp. 1047 – 1054, 1997, Copyright © 1997 Elsevier Science I
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