Non-functioning (GULO) Enzyme in the Biosynthesis of Ascorbic Acid in guinea pigs, primates and humans. | General Discussion Topics | Forum


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Non-functioning (GULO) Enzyme in the Biosynthesis of Ascorbic Acid in guinea pigs, primates and humans.
June 30, 2016
4:06 pm
Forum Posts: 147
Member Since:
January 28, 2015
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A quote from the late Dr. Irwin Stone. “The evidence we unearth will show that the lack of this molecule (L-gulonolactone oxidase enzyme) in humans has contributed to more deaths, sickness, and just plain misery than any other single factor in man’s long history. When the molecule is finally discovered and assigned its rightful place in the scheme of things, and its potentialities for good are fully realized, undreamed-of vistas of exuberant health, freedom from disease, and long life will be opened up.”

What is absolutely astounding is the fact that modern medical science does not consider the "missing" L-gulonolactone molecule a medical problem. Every human being on the planet Earth is hypoascorbemic. Being hypoascorbemic has made every man, woman and child susceptible to a whole range of subclinical scurvy diseases:

  1. Mild cold
  2. Severe Cold
  3. Influenza
  4. ECHO (Enteric Cytopathogenic Human Orphan Group), Coxsackievirus (group of viruses that lead to gastrointestinal infection and skin rashes)
  5. Mononucleosis
  6. Viral Pneumonia
  7. Hay Fever, Environmental Asthma and Food Allergy.
  8. Burns, injury, surgery anxiety, exercise, and other mild stresses.
  9. Cancer
  10. Ankylosing Spondylitis (chronic inflammatory disease of the axial skeleton)
  11. Reiters Syndrome (Reactive arthritis)
  12. Acute Anterior Uveitis (inflammation of the middle layer of the eye)
  13. Rheumatoid Arthritis
  14. Bacterial Infections
  15. Hepatitis Infection
  16. Candidiasis (fungal infection)
  17. Scarlet Fever
  18. Herpes: Cold Sores, Genital Lesions, and Shingles
  19. Crib Deaths (Sudden Infant Death Syndrome)

 The pathway is:

                           UDP- glucose dehydrogenase

1.   UDP –glucose ---------------------------------------------⇒ UDP-glucuronic acid


2.   UDP-glucuronic acid ----------------------- ⇒  D- Glucuronic acid


                            Glucuronic acid dehydrogenase

3.   D-Glucuronic acid ------------------------------⇒  L-gulonic acid 



4.   L-gulonic acid   ----------------------------------⇒ L-gulonolactone


                              Gulonolactone Oxidase*

 5.  L-gulonolactone  ---------------------------⇒  2-keto-L-gulonolactone

                                   spontaneous (when enzyme is not missing)

6.   2-keto-L-gulonolactone ---------------⇒ L-ascorbic acid (vitamin C)


* missing in guinea pigs, primates and humans.

  - How can this missing enzyme be a "survival advantage" for humans?

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